Serving Size: 1 Capsule
Servings Per Container: 56
|Amount Per Serving||% Daily Value*|
|*Percent Daily Value (DV) are based on a 2000 calorie diet.|
|†Daily Value (DV) not established.|
The good ol’ blood, sweat and tears
Oh, yeah, buddy: you’ve got it. Long weeks of heavy pumping, your training partner singing the same song on your ear in every workout (“Burn, baby! Burn!”), strong dieting and a sound pro hormone cycle. You’re glad with the results and you worth having gone every night to the bed blessed with Arnold’s philosophy of no pain, no gain.
Thus, towards the end of a typical 6-8cycle, you’ve have gained considerable muscle and strength.
So what happens next?
POWERFUL NATURALSELECTIVE ESTROGEN RECEPTOR MODULATOR
SHBG (sex hormone-binding globulin) is a protein produced primarily in the liver, although the testes, uterus, brain, and placenta also synthesize it. It serves as a transport carrier, shuttling estrogen and testosterone to sex hormone receptors throughout your body. SHBG also safeguards these vital hormones from degrading too rapidly and prevents their clearance from the body.
It thus acts as the master regulator of your sex hormone levels, maintaining the delicate balance between estrogen and testosterone critical to overall health and to the maintenance of your gains.
This complicated molecule itself plays another key role in the body: conveying essential signals to the heart, the brain and adipose (fat) tissue that ensure their optimal function. Mother nature even gave you a special SHBG receptor molecule on cell surfaces that functions much like the ubiquitous vitamin D receptor protein, helping cells communicate with one another. In other words, SHBG itself functions much like a hormone.
Most testosterone circulating in the bloodstream is bound to either SHBG
(60%) or albumin (38%): only a small fraction (2%) is unbound or “free” (pal, are you still with me?).
Testosterone binds more tightly to SHBG than to albumin. Consequently, only albumin-bound testosterone and free testosterone constitute the bioavailable forms of testosterone, which are accessible to target tissues and carry out the actions of the essential hormone. So, in a nutshell, the bioavailability of testosterone is influenced by the level of SHBG.
Now, we’re talking. The balance between estrogen and testosterone is extremely important for you: what is disastrous for you is excess estrogen. An effective post cycle therapy must provide you with a powerful natural selective estrogen receptor modulator, preventing the catastrophe of estrogen dominance after weeks of blood, sweat and tears and assuring an balanced environment between estrogen and testosterone.
Adaptogen Science’sAIT® is an innovative formula designed to support yourgains, while keeping SHBG in check.
Heavy workout fellows using pro-hormone cyclesexperience both an increase in aromatase activity and an elevation in SHBGproduction. The net result is an increase in the ratio of estrogen totestosterone and a decrease in total and free testosterone levels: for theirown sake, it is crucial that this skewed ratio be balanced.
After a cycle is discontinued, the prohormonesused rapidly leave the body and many guys may bedelusional enough to think the gains made while they’re on cycle were all downto them.
The ideal formula must provide you with thepower of speeding the pre-cycle environment, thus controlling aromataseactivity. The ingredients for that goes as follows:
Theperennial herb Tinospora cordifoliais distributed throughout the tropical and subtropical Indian subcontinent andChina. In India, it is fairly common inhabitant of deciduous and dry forests,growing over hedges and small trees. It is one of the major constituent ofseveral Ayurvedic preparation used preferably for general debility, dyspepsia,fever and urinary diseases.
Apart frommany other studies, the hepato-protective and anti-aromatase potentialsvalidated with respect to Tinosporacordifolia by scientific research includes:
The chemicalconstituents reported in Tinosporacordiofolia belongs to different classes such as alkaloids, di-terpenoidlactones, glycosides, steroids, sesquiterpenoids, phenolics, aliphaticcompounds and polysaccharides.
This potentformula allows you to obtain a huge variety of benefits linked to your goals:
PROTECTS MUSCLEMASS GAINS WHILE “ON”
The liver is responsible for removing excess estrogen and SHBG, and anydecrease in liver function could exacerbate hormonal imbalances and compromise theferocious testosterone levels you’re looking for. If you don’t mind your liver,instead of looking a demigod after a prohormone cycle you may look a pregnantcow with the characteristic bitch tits. Thus it is important that post-cycleboys also strive for optimal liver function.
Adaptogen Science’s AIT® assures you to benefit of apowerful liver methylation formula, with two powerful naturals substances:
Kudzu (Pueraria lobata) is a climbing vinethat belongs to the pea family. Its flowers and starchy white roots have beenused in traditional Chinese medicine for centuries. Kudzu root is rich in isoflavone glucosides, themost abundant of which are puerarin (daidzein 8-C-glucoside), daidzein anddaidzin (daidzein 7-C glucoside). Essentially, puerarin acts as a traffic cop,regulating glucose by directing toward muscles and away from fat cells andblood vessels.
Puerarin binds to the estrogen receptors in the bodyand because it brings a lower dose of estrogen to the receptors, it can preventthe body from overproducing estradiol. Estradiol and progesterone are anenergetic pair [yin (estradiol) yang (progesterone)]. When estradiol is loweredprogesterone will naturally be raised. Instead of bringing in an outside sourceof progesterone, this protocol give the body a chance find its ownestradiol-progesterone balance.
Kudzu isassociaed with an attenuation of the rise of adiponectin, which bring serumconcentrations to a level similar to lean controls.
Kudzu extract also stabilizes the activity of liverenzymes, stimulates regeneration of liver tissue, and makes the liver moreresistant to damage from an anabolic cycle.
SAMe (S-adenosyl methionine)
SAMe (S-adenosyl-methionine)is an amino acid derivative normally synthesized in the body and used by thebody in three important pathways:
Itis concentrated in the liver and brain and is a major methyl donor in thesynthesis of hormones, nucleic acids, proteins, and phospholipids,catecholamines, and other neurotransmitters, such as dopamine and serotonin.
Itis required for the synthesis of norepinephrine, dopamine, and serotonin, andalso plays a role in other intracellular metabolic pathways. Besides, itfacilitates glutathione usage and maintains acetylcholine levels, which helpenhance or maintain cognitive function and attenuate or prevent aggression.
SAMelevels may become depleted from sickness and age. There is evidence that ithelps to synthesize phosphatidylcholine, which keeps cell membranes fluid, andis used in the brain to make the neurotransmitter acetylcholine.
Thisamino acid has multiple mechanisms of action that are used throughout the body,especially in the liver, which help maintain liver health. It facilitateshealthy methylation enzymatic processes and boosts hepatic levels of thecritical antioxidant glutathione. When liver function is compromised,glutathione is depleted, which leads to free radical damage.
Medical studies have shown that SAMe has beneficialantioxidant effects on the liver and other tissues, particularly in protectingand restoring liver cell function destroyed by drugs, viruses and environmentaltoxins. It decreases the production of liver collagen (typical feature of anyanabolic cycle), which leads to the formation of fibrous tissue.
Milk thistleis an edible plant, and its leaves can be eaten like artichokes. The seeds canbe roasted and brewed like coffee. This herb contains antioxidants, cellmembrane-stabilizing agents, bile secretion-enhancing compounds, or nutrientsthat prevent depletion of endogenous antioxidants such as glutathione.
Silybum marianum, a constituent of milk thistle, hasbeen used for over 2,000 years as a traditional medicine specifically for liverailments. Milk thistle protects liver tissue; hastens the restoration of livercells in damaged liver tissue; decreases liver and bile cholesterol; alleviatesinflammation; and limits liver damage resulting from a disrupted oxygen supply
Scientifically,researchers have found that silymarin, as well as an isolated form offlavonolignan called silybin, can prevent or counteract damage to the livercaused by toxins such as alcohol, acetaminophen (Tylenol) and other drugs, aswell as environmental (heavy metals) and bacterial toxins, and even poisonssuch as those found in the lethal Deathcap mushroom. It also counteracts thestressful effects of an anabolic cycle on the liver, such as lipid peroxidation.The main mechanism of liver damage while on cycle is the depletion ofglutathione and silymarin and silybin actually elevated glutathione levels.
Silybinin also has a crucial rule on the typical adipogenesis that mayoccur after an anabolic cycle. It presence in pre-differentiated adipocytesappears to concentration-dependently reduce differentiation and triglycerideaccumulation. Besides, a highly significant suppression of adipogenic markers isnormally observed.
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2. Abenavoli L, et al. Complementary therapies for treatingalcoholism First Annual meeting by Complementary Medicine Research Group of theItalian Society for Alcohol Studies-May 5, 2006, Florence, Italy.Fitoterapia. (2008)
3. Pradhan SC, Girish C. Hepatoprotective herbal drug,silymarin from experimental pharmacology to clinical medicine.Indian J Med Res. (2006)
4. Kroll DJ, Shaw HS, OberliesNH. Milk thistle nomenclature: why itmatters in cancer research and pharmacokinetic studies.Integr Cancer Ther. (2007)
5. Kim NC, et al. Complete isolation andcharacterization of silybins and isosilybins from milk thistle (Silybummarianum). Org Biomol Chem.(2003)
6. Lee DY, Liu Y. Molecular structure andstereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B,Isolated from Silybum marianum (milk thistle).J Nat Prod. (2003)
8. Kidd PM. Bioavailability and activity ofphytosome complexes from botanical polyphenols: the silymarin, curcumin, greentea, and grape seed extracts. Altern MedRev. (2009)
9. Sheu SY, Lai CH, Chiang HC. Inhibition of xanthine oxidase by purpurogallinand silymarin group. AnticancerRes. (1998)
10. Pauff JM, Hille R. Inhibition studies of bovine xanthineoxidase by luteolin, silibinin, quercetin, and curcumin.J Nat Prod. (2009)
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